Selected Publications

For a full list of publications, please visit the Google Scholar page.
Note: * = equal contribution, # = correspondence

A Clinically-Oriented Foundation Model for Intraoperative Pathology

Zihan Zhao, Fengtao Zhou, Ronggang Li*, Bing Chu, Xinke Zhang, Xueyi Zheng, Ke Zheng, Xiaobo Wen, Jiabo Ma, Yihui Wang, Jiewei Chen, Chengyou Zheng, Jiangyu Zhang, Yongqin Wen, Jiajia Meng, Ziqi Zeng, Xiaoqing Li, Jing Li, Dan Xie, Yaping Ye, Yu Wang, Hao Chen#, Muyan Cai#

Nature Medicine, 2026

GitHub Repository: FT-ZHOU-ZZZ/CRISP

Model Weights
Public Dataset

Large-scale Multi-sequence Pretraining for Generalizable MRI Analysis in Versatile Clinical Applications

Zelin Qiu, Xi Wang, Zhuoyao Xie*, Juan Zhou, Yu Wang, Lingjie Yang, Xinrui Jiang, Juyoung Bae, Moo Hyun Son, Qiang Ye, Dexuan Chen, Rui Zhang, Tao Li, Neeraj Ramesh Mahboobani, Varut Vardhanabhuti, Xiaohui Duan#, Yinghua Zhao#, Hao Chen#

Nature Biomedical Engineering, 2026

GitHub Repository: zqiuak/MARS

Model Weights

GSCo: Towards Generalizable AI in Medicine via Generalist-Specialist Collaboration

Sunan He, Yuxiang Nie, Hongmei Wang, Shu Yang, Yihui Wang, Zhiyuan Cai, Zhixuan Chen, Yingxue Xu, Luyang Luo, Huiling Xiang, Xi Lin, Mingxiang Wu, Yifan Peng, George Shih, Ziyang Xu, Xian Wu, Qiong Wang, Ronald Cheong Kin Chan, Varut Vardhanabhuti, Winnie Chiu Wing Chu, Yefeng Zheng, Pranav Rajpurkar, Kang Zhang, Hao Chen#

Nature Biomedical Engineering, 2026

GitHub Repository: sunanhe/MedDr

GSCI Generalist Model Weights
GSCo Specialist Model Weights
Project Page
Dataset Access Guide

Segment Anything in Pathology Images with Natural Language

Zhixuan Chen, Junlin Hou, Liqi Lin, Yihui Wang, Yequan Bie, Xi Wang, Yanning Zhou, Danyi Li, Hongxuan Tan, Li Liang, Ronald Cheong Kin Chan, Hao Chen#

Nature Computational Science, 2026

GitHub Repository: zhi-xuan-chen/PathSegmentor

Model Weights

Generative AI for Misalignment-Resistant Virtual Staining to Accelerate Histopathology Workflows

Jiabo Ma, Wenqiang Li, Jinbang Li, Ziyi Liu, Linshan Wu, Fengtao Zhou, Li Liang, Ronald Cheong Kin Chan, Terence T. W. Wong, Hao Chen#

Nature Communications, 2026

GitHub Repository: birkhoffkiki/DTR

Model Weights
Preprint

Large-scale Self-supervised Video Foundation Model for Intelligent Surgery

Shu Yang, Fengtao Zhou, Leon Mayer, Fuxiang Huang, Yiliang Chen, Yihui Wang, Sunan He, Yuxiang Nie, Xi Wang, Yueming Jin, Huihui Sun, Shuchang Xu, Alex Qinyang Liu, Zheng Li, Jing Qin, Jeremy YuenChun Teoh, Lena Maier-Hein#, Hao Chen#

npj Digital Medicine, 2026

GitHub Repository: isyangshu/SurgVISTA

Preprint

A Generalizable Pathology Foundation Model Using a Unified Knowledge Distillation Pretraining Framework

Jiabo Ma, Zhengrui Guo, Fengtao Zhou, Yihui Wang, Yingxue Xu, Jinbang Li, Fang Yan, Yu Cai, Zhengjie Zhu, Cheng Jin, Yi Lin, Xinrui Jiang, Anjia Han, Zhenhui Li, Ronald Cheong Kin Chan, Jiguang Wang, Peng Fei, Kwang-Ting Cheng, Shaoting Zhang#, Li Liang#, Hao Chen#

Nature Biomedical Engineering, 2025

GitHub Repository: birkhoffkiki/GPFM

Model Weights
Preprint

Large-Scale 3D Medical Image Pre-Training With Geometric Context Priors

Linshan Wu, Jiaxin Zhuang, Hao Chen#

IEEE Transactions on Pattern Analysis and Machine Intelligence, 2025

GitHub Repository: Luffy03/Large-Scale-Medical

Large-scale Generative Tumor Synthesis in Computed Tomography Images for Improving Tumor Recognition

Linshan Wu, Jiaxin Zhuang, Yanning Zhou, Sunan He, Jiabo Ma, Luyang Luo, Xi Wang, Xuefeng Ni, Xiaoling Zhong, Mingxiang Wu, Yinghua Zhao, Xiaohui Duan, Varut Vardhanabhuti, Pranav Rajpurkar, Hao Chen#

Nature Communications, 2025

GitHub Repository: Luffy03/FreeTumor

Model Weights
Processed Organ and Tumor Labels
Public Downstream Datasets

A Multimodal Knowledge-enhanced Whole-slide Pathology Foundation Model

Yingxue Xu, Yihui Wang, Fengtao Zhou*, Jiabo Ma, Cheng Jin, Shu Yang, Jinbang Li, Zhengyu Zhang, Chenglong Zhao, Huajun Zhou, Zhenhui Li, Huangjing Lin, Xin Wang, Jiguang Wang, Anjia Han, Ronald Cheong Kin Chan, Li Liang, Xiuming Zhang, Hao Chen#

Nature Communications, 2025

GitHub Repository: Innse/mSTAR

Model Weights (Access on Request)
Archived Code
Preprint

A Large Model for Non-Invasive and Personalized Management of Breast Cancer from Multiparametric MRI

Luyang Luo, Mingxiang Wu, Mei Li, Yi Xin, Qiong Wang, Varut Vardhanabhuti, Winnie CW Chu, Zhenhui Li#, Juan Zhou#, Pranav Rajpurkar, Hao Chen#

Nature Communications, 2025

GitHub Repository: LLYXC/MOME

Model Weights
Sample Data
Official Code Release

Foundation Model for Advancing Healthcare: Challenges, Opportunities and Future Directions

Yuting He, Fuxiang Huang, Xinrui Jiang, Yuxiang Nie, Minghao Wang, Jiguang Wang, Hao Chen#

IEEE Reviews in Biomedical Engineering, 2024

GitHub Repository: YutingHe-list/Awesome-Foundation-Models-for-Advancing-Healthcare

Selected Publications

Zihan Zhao*, Fengtao Zhou*, Ronggang Li*, Bing Chu, Xinke Zhang, Xueyi Zheng, Ke Zheng, Xiaobo Wen, Jiabo Ma, Yihui Wang, Jiewei Chen, Chengyou Zheng, Jiangyu Zhang, Yongqin Wen, Jiajia Meng, Ziqi Zeng, Xiaoqing Li, Jing Li, Dan Xie, Yaping Ye, Yu Wang, Hao Chen#, Muyan Cai#

Zelin Qiu*, Xi Wang*, Zhuoyao Xie*, Juan Zhou, Yu Wang, Lingjie Yang, Xinrui Jiang, Juyoung Bae, Moo Hyun Son, Qiang Ye, Dexuan Chen, Rui Zhang, Tao Li, Neeraj Ramesh Mahboobani, Varut Vardhanabhuti, Xiaohui Duan#, Yinghua Zhao#, Hao Chen#

Zhixuan Chen*, Junlin Hou*, Liqi Lin, Yihui Wang, Yequan Bie, Xi Wang, Yanning Zhou, Danyi Li, Hongxuan Tan, Li Liang, Ronald Cheong Kin Chan, Hao Chen#

Jiabo Ma*, Wenqiang Li*, Jinbang Li, Ziyi Liu, Linshan Wu, Fengtao Zhou, Li Liang, Ronald Cheong Kin Chan, Terence T. W. Wong, Hao Chen#

Shu Yang, Fengtao Zhou, Leon Mayer, Fuxiang Huang, Yiliang Chen, Yihui Wang, Sunan He, Yuxiang Nie, Xi Wang, Yueming Jin, Huihui Sun, Shuchang Xu, Alex Qinyang Liu, Zheng Li, Jing Qin, Jeremy YuenChun Teoh, Lena Maier-Hein#, Hao Chen#

Jiabo Ma*, Zhengrui Guo*, Fengtao Zhou, Yihui Wang, Yingxue Xu, Jinbang Li, Fang Yan, Yu Cai, Zhengjie Zhu, Cheng Jin, Yi Lin, Xinrui Jiang, Anjia Han, Zhenhui Li, Ronald Cheong Kin Chan, Jiguang Wang, Peng Fei, Kwang-Ting Cheng, Shaoting Zhang#, Li Liang#, Hao Chen#

Linshan Wu, Jiaxin Zhuang, Hao Chen#

Linshan Wu, Jiaxin Zhuang, Yanning Zhou, Sunan He, Jiabo Ma, Luyang Luo, Xi Wang, Xuefeng Ni, Xiaoling Zhong, Mingxiang Wu, Yinghua Zhao, Xiaohui Duan, Varut Vardhanabhuti, Pranav Rajpurkar, Hao Chen#

Yingxue Xu*, Yihui Wang*, Fengtao Zhou*, Jiabo Ma, Cheng Jin, Shu Yang, Jinbang Li, Zhengyu Zhang, Chenglong Zhao, Huajun Zhou, Zhenhui Li, Huangjing Lin, Xin Wang, Jiguang Wang, Anjia Han, Ronald Cheong Kin Chan, Li Liang, Xiuming Zhang, Hao Chen#

Luyang Luo, Mingxiang Wu, Mei Li, Yi Xin, Qiong Wang, Varut Vardhanabhuti, Winnie CW Chu, Zhenhui Li#, Juan Zhou#, Pranav Rajpurkar, Hao Chen#

Yuting He, Fuxiang Huang, Xinrui Jiang, Yuxiang Nie, Minghao Wang, Jiguang Wang, Hao Chen#

Zihan Zhao, Fengtao Zhou, Ronggang Li*, Bing Chu, Xinke Zhang, Xueyi Zheng, Ke Zheng, Xiaobo Wen, Jiabo Ma, Yihui Wang, Jiewei Chen, Chengyou Zheng, Jiangyu Zhang, Yongqin Wen, Jiajia Meng, Ziqi Zeng, Xiaoqing Li, Jing Li, Dan Xie, Yaping Ye, Yu Wang, Hao Chen#, Muyan Cai#

Zelin Qiu, Xi Wang, Zhuoyao Xie*, Juan Zhou, Yu Wang, Lingjie Yang, Xinrui Jiang, Juyoung Bae, Moo Hyun Son, Qiang Ye, Dexuan Chen, Rui Zhang, Tao Li, Neeraj Ramesh Mahboobani, Varut Vardhanabhuti, Xiaohui Duan#, Yinghua Zhao#, Hao Chen#

Zhixuan Chen, Junlin Hou, Liqi Lin, Yihui Wang, Yequan Bie, Xi Wang, Yanning Zhou, Danyi Li, Hongxuan Tan, Li Liang, Ronald Cheong Kin Chan, Hao Chen#

Jiabo Ma, Wenqiang Li, Jinbang Li, Ziyi Liu, Linshan Wu, Fengtao Zhou, Li Liang, Ronald Cheong Kin Chan, Terence T. W. Wong, Hao Chen#

Jiabo Ma, Zhengrui Guo, Fengtao Zhou, Yihui Wang, Yingxue Xu, Jinbang Li, Fang Yan, Yu Cai, Zhengjie Zhu, Cheng Jin, Yi Lin, Xinrui Jiang, Anjia Han, Zhenhui Li, Ronald Cheong Kin Chan, Jiguang Wang, Peng Fei, Kwang-Ting Cheng, Shaoting Zhang#, Li Liang#, Hao Chen#

Yingxue Xu, Yihui Wang, Fengtao Zhou*, Jiabo Ma, Cheng Jin, Shu Yang, Jinbang Li, Zhengyu Zhang, Chenglong Zhao, Huajun Zhou, Zhenhui Li, Huangjing Lin, Xin Wang, Jiguang Wang, Anjia Han, Ronald Cheong Kin Chan, Li Liang, Xiuming Zhang, Hao Chen#